https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Differential airway remodeling changes were observed in patients with asthma COPD overlap compared to patients with asthma and COPD alone https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51924 Wed 28 Feb 2024 09:57:50 AEDT ]]> Pathways linked to unresolved inflammation and airway remodelling characterize the transcriptome in two independent severe asthma cohorts https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50107 Wed 12 Jul 2023 13:43:56 AEST ]]> Investigation of pathogenesis of chronic obstructive pulmonary disease https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23630 Wed 11 Apr 2018 17:16:57 AEST ]]> Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin-1c https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33793 –/–) mice had reduced mucin (MUC) 5 AC levels, but not MUC5B levels, in the airways as compared with wild‐type (WT) mice. Fbln1c interacted with fibronectin and periostin that was linked to collagen deposition around the small airways. Fbln1c–/– mice with AAD also had reduced numbers of α‐smooth muscle actin‐positive cells around the airways and reduced airway contractility as compared with WT mice. After HDM challenge, these mice also had fewer airway inflammatory cells, reduced interleukin (IL)‐5, IL‐13, IL‐33, tumour necrosis factor (TNF) and CXCL1 levels in the lungs, and reduced IL‐5, IL‐33 and TNF levels in lung‐draining lymph nodes. Therapeutic targeting of Fbln1c reduced the numbers of GATA3‐positive Th2 cells in the lymph nodes and lungs after chronic HDM challenge. Treatment also reduced the secretion of IL‐5 and IL‐13 from co‐cultured dendritic cells and T cells restimulated with HDM extract. Human epithelial cells cultured with Fbln1c peptide produced more CXCL1 mRNA than medium‐treated controls. Our data show that Fbln1c may be a therapeutic target in chronic asthma.]]> Thu 28 Oct 2021 13:02:39 AEDT ]]> Blocking induction of T helper type 2 responses prevents development of disease in a model of childhood asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17925 Sat 24 Mar 2018 07:56:24 AEDT ]]> The 'classical' ovalbumin challenge model of asthma in mice https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:5604 Sat 24 Mar 2018 07:49:22 AEDT ]]> Suppression of cytokine expression by roflumilast and dexamethasone in a model of chronic asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4804 Sat 24 Mar 2018 07:20:43 AEDT ]]> Epithelial cell dysfunction, a major driver of asthma development https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38659 Mon 29 Jan 2024 17:49:38 AEDT ]]> Pathophysiology of severe asthma: We've only just started https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47496 Mon 23 Jan 2023 11:54:34 AEDT ]]>